Beta-2 adrenergic receptor
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چکیده
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream Ltype calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Unlike other adrenergic receptors, norepinephrine does not produce β2 receptor stimulation. The official symbol for the human gene encoding the β2 adrenoreceptor is ADRB2.[3]
منابع مشابه
Effects of three beta adrenergic receptor agonists on growth performance, blood biochemical parameters, fatty acids composition and carnitine palmitoyltransferase I gene expression of rainbow trout Oncorhynchus mykiss
Different beta 1 and 2 adrenergic receptor agonists may be various biological and physiological effects on fish species. An experiment was designed to study the effects of feeding ractopamine, terbutaline and metaproterenol; as beta1, beta2 and less selective beta 2 adrenergic receptor agonists, respectively; on body weight gain, feed conversion ratio, concentration of biochemical parameters in...
متن کاملEffects of three beta adrenergic receptor agonists on growth performance, blood biochemical parameters, fatty acids composition and carnitine palmitoyltransferase I gene expression of rainbow trout, Oncorhynchus mykiss
Different beta 1 and 2 adrenergic receptors agonists might have various biological and physiological effects on fish species. An experiment was designed to study the effects of feeding ractopamine, terbutaline and metaproterenol; as beta1, beta2 and less selective beta2 adrenergic receptor agonists, respectively; on body weight gain, feed conversion rate, concentration of biochemical parameters...
متن کاملThe Role of Adrenergic Receptors on Neural Excitability and Synaptic Plasticity: A Narrative Review
Adrenergic receptors have an important role in neural excitability and synaptic plasticity. Despite a lot of studies on these receptors, their exact role in brain disorders accompanied with hyperexcitability has not been determined. There are also controversies on their role in synaptic plasticity. In this review article, the important studies done in this regard have been reviewed to achieve a...
متن کاملتأثیر بیماریها بر پاسخدهی گیرنده های بتا - آدرنرژیک
The development of radioligand - binding studies has greatly advanced our knowledge of the molecular pharmacology of beta - adrenoceptors. Using this technique it became possible for the first time to directly determine the tissue concentration of beta - adrenoceptors, and by this, the responsiveness of tissues to beta - adrenergic stimulation. One major insight into the molecular pharmacology ...
متن کاملA Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study
Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...
متن کاملA Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study
Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...
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